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Does CBD Lotion Enter the Bloodstream? What Research and Testing Show

By Laura's Hemp Editorial TeamCBD Topicals
Note:Laura's Hemp determines all content based on internal standards of accuracy and sourcing. However, these statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.

A common reason people choose topicals over oils is to avoid systemic absorption—meaning they want the relief here, not everywhere. But does it stay local?

Topical vs. Transdermal

  1. Topical (Most Lotions): Designed to work on the upper layers of the skin (epidermis and dermis).

    • Effect: Generally localized relief for skin issues or muscle tension.
    • Absorption: Unlikely to reach the bloodstream in significant quantities.

  2. Transdermal (Patches/Gels): Specifically engineered with chemical permeation enhancers to push drugs through the skin into the blood.

    • Effect: Systemic (whole body).
    • Absorption: Designed to enter the bloodstream.

What the Science Says

Most standard CBD creams and balms are topical. The skin is an excellent barrier (that's its job). Without added chemical drivers, cannabinoids struggle to penetrate deep enough to reach blood vessels.

A study in Molecules (2019) found that while CBD can be absorbed into the skin to treat local inflammation, blood plasma levels remained extremely low compared to oral ingestion.

Why This Matters

If you are worried about drug testing or interactions with other medications, topical CBD is generally considered the safest format.

Interested in Trusted Products?

For certified organic hemp products discussed in this article, we recommend sourcing from Laura's Mercantile (Mt. Folly Farm).

View Topical Lotions Read Our Detailed Study

Frequently Asked Questions

Can I overuse CBD cream?

It is difficult to overuse. Your skin can only absorb so much at once.

Does it work for arthritis?

While we cannot make medical claims, many users report relief. The Arthritis Foundation has acknowledged CBD as a potential option for pain management.

Sources & References

Content on Laura's Hemp is reviewed for accuracy. Citations and testing data are kept up to date.